Flumazenil

Section 8 - MEDICATION GUIDELINES

ANTAGONISTS

Flumazenil (ROMAZICON) / Antagonist

DESCRIPTION

• It is a benzodiazepine antagonist.

INDICATIONS

• Inadvertent overmedication with VERSED or VALIUM

CONTRAINDICATIONS

• Hypersensitivity to the medication, Tricyclic antidepressant overdoses.

PRECAUTIONS

• Use with caution in cases of mixed overdose, adverse reactions include arrhythmias and seizures.

DOSAGE

• Usual dosage is 0.2 mg IV over 15 seconds; wait 45 seconds, then give 0.2 mg if consciousness does not occur; may be repeated 60 second intervals prn, up to 4 additional doses-max 1 mg.
• Refer to Handtevy System for pediatric specific dosages
  • Premie - 5 y/o: 0.01 mg/kg
  • 6 years and older: 0.2 mg