Antihistamines
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Contents
Section 8 - MEDICATION GUIDELINES
8.10 ANTIHISTAMINES
Diphenhydramine (BENADRYL) / Antihistamine
DESCRIPTION
- Inhibits the release of histamine, thereby reducing brocho-constriction and vasodilatation.
INDICATIONS
- Allergic reaction. Dystonic reactions to antiphychotics.
CONTRAINDICATIONS
- Anaphylactic Shock
PRECAUTIONS
- May induce hypotension, headache, Tachycardia, sedation, drowsiness, and /or disturbed coordination.
- Use with caution in patients with asthma and other lower respiratory diseases due to the potential for dyspnea.
DOSAGE
- Adult: 1 mg/ kg up to 50 mg IVP AND refer to the appropriate PRACTICE PARAMETER for specific dosages.
- For PO administration:
- 1 mg/kg. Currently supplied in 12.5mg/5ml.
- For PO administration:
- Pediatrics: Refer to Handtevy System for specific dosages
- 1 mg/kg up to 50 mg IVP
- 1mg/kg for PO (12.5mg/5mL)
Famotidine (PEPCID) / H2 Histamine blocker
DESCRIPTION
- Famotidine inhibits histamine at H2 receptor site in the gastric parietal cell, which inhibits gastric acid secretion.
INDICATIONS
- Hives; Allergic reaction; Short term treatment of duodenal and gastric ulcers, management of GERD and erosive esophagitis.
CONTRAINDICATIONS
- Hypersensitivity to the medication
- Renal impairment
PRECAUTIONS
- Hepatic disease, renal disease, elderly
DOSAGE
- Currently supplied in 20mg/50 ml
- Adults: 20mg/ 50ml given at a wide open rate.
- Pediatrics- refer to the Handtevy System.
