Difference between revisions of "Anti-Fibrinolytic"
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* Inhibits both plasminogen activation and plasmin activity, thus preventing clot break-down rather than promoting new clot formation. With massive bleeding this may help stabilize clot formation and decrease extravascular bleeding. | * Inhibits both plasminogen activation and plasmin activity, thus preventing clot break-down rather than promoting new clot formation. With massive bleeding this may help stabilize clot formation and decrease extravascular bleeding. | ||
'''INDICATIONS''' | '''INDICATIONS''' | ||
| − | * [[Severe Hemorrhagic Shock]]. | + | * [[Hemorrhagic Shock|Severe Hemorrhagic Shock]]. |
| + | *Strongly consider in non-traumatic bleeding (post-partum, gastrointestinal, postoperative, nasal) | ||
| + | |||
| + | '''PREGNANCY CATEGORY''' | ||
| + | * B - Safe in Pregnancy | ||
| + | * Safe in breastfeeding | ||
| + | |||
'''CONTRAINDICATIONS''' | '''CONTRAINDICATIONS''' | ||
| − | * | + | * Hypersensitivity to TXA |
| − | * | + | * Colorblindness |
| − | * | + | * History of Seizures |
| − | * | + | * Ischemic event: Myocardial Infarction, stroke, pulmonary embolism (PE), deep venous thrombosis (DVT) |
| + | * Isolated head injury / subarachnoid hemorrhage | ||
| + | |||
'''PRECAUTIONS''' | '''PRECAUTIONS''' | ||
* Rapid injection can cause hypotension | * Rapid injection can cause hypotension | ||
'''DOSAGE''' | '''DOSAGE''' | ||
| − | * 1000 mg of TXA mixed in 100 ml or 250 ml of normal saline infused via IO or IV over 10 minutes. | + | * 1000 mg of TXA mixed in 100 ml or 250 ml of normal saline infused via IO or IV over 10 minutes. |
| + | * 20mg/kg (1000mg maximum) TXA mixed in 100 ml of Normal Saline infused via IO or IV over 10 minutes. | ||
[[Category:Medication Guidelines|0819]] | [[Category:Medication Guidelines|0819]] | ||
Revision as of 05:12, 19 November 2019
Section 8 - MEDICATION GUIDELINES
8.20 ANTI-FIBRINOLYTICS
Tranexamic Acid (TXA)
DESCRIPTION
- Inhibits both plasminogen activation and plasmin activity, thus preventing clot break-down rather than promoting new clot formation. With massive bleeding this may help stabilize clot formation and decrease extravascular bleeding.
INDICATIONS
- Severe Hemorrhagic Shock.
- Strongly consider in non-traumatic bleeding (post-partum, gastrointestinal, postoperative, nasal)
PREGNANCY CATEGORY
- B - Safe in Pregnancy
- Safe in breastfeeding
CONTRAINDICATIONS
- Hypersensitivity to TXA
- Colorblindness
- History of Seizures
- Ischemic event: Myocardial Infarction, stroke, pulmonary embolism (PE), deep venous thrombosis (DVT)
- Isolated head injury / subarachnoid hemorrhage
PRECAUTIONS
- Rapid injection can cause hypotension
DOSAGE
- 1000 mg of TXA mixed in 100 ml or 250 ml of normal saline infused via IO or IV over 10 minutes.
- 20mg/kg (1000mg maximum) TXA mixed in 100 ml of Normal Saline infused via IO or IV over 10 minutes.
