Mfrdmanager: Created page with "==Section 8 - MEDICATION GUIDELINES== ===ANTI-FIBRINOLYTICS=== ====Tranexamic Acid (TXA)==== '''DESCRIPTION''' * Inhibits both plasminogen activation and plasmin activity, t..."

2020-11-12T19:39:49Z

Created page with "==Section 8 - MEDICATION GUIDELINES== ===ANTI-FIBRINOLYTICS=== ====Tranexamic Acid (TXA)==== '''DESCRIPTION''' * Inhibits both plasminogen activation and plasmin activity, t..."

New page

==Section 8 - MEDICATION GUIDELINES==
===ANTI-FIBRINOLYTICS===

====Tranexamic Acid (TXA)====

'''DESCRIPTION'''
* Inhibits both plasminogen activation and plasmin activity, thus preventing clot break-down rather than promoting new clot formation. With massive bleeding this may help stabilize clot formation and decrease extravascular bleeding.
'''INDICATIONS'''
* [[Hemorrhagic Shock|Severe Hemorrhagic Shock]] or imminent shock.
*Strongly consider in non-traumatic major bleeding (post-partum, gastrointestinal, postoperative, nasal) with signs of shock or imminent shock.

'''PREGNANCY CATEGORY'''
* B - Safe in Pregnancy
* Safe in breastfeeding

'''CONTRAINDICATIONS'''
* Hypersensitivity to TXA
* Colorblindness
* History of Seizures
* Ischemic event: Myocardial Infarction, stroke, pulmonary embolism (PE), deep venous thrombosis (DVT)
* Isolated head injury / subarachnoid hemorrhage

'''PRECAUTIONS'''
* Rapid injection can cause hypotension
'''DOSAGE'''
* 1000 mg of TXA mixed in 100 ml or 250 ml of normal saline infused via IO or IV over 10 minutes.
* 20mg/kg (1000mg maximum) TXA mixed in 100 ml of Normal Saline infused via IO or IV over 10 minutes.

[[Category:Medication Guidelines|TXA]]

TXA - Revision history

Mfrdmanager: Created page with "==Section 8 - MEDICATION GUIDELINES== ===ANTI-FIBRINOLYTICS=== ====Tranexamic Acid (TXA)==== '''DESCRIPTION''' * Inhibits both plasminogen activation and plasmin activity, t..."